Anti-CIP2A Polyclonal Antibody
應(yīng)用 WB
稀釋比例WB 1:500-2000.
交叉反應(yīng)Human

產(chǎn)品型號(hào)：K106617P

更新時(shí)間：2022-08-15

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Anti-CIP2A Polyclonal Antibody

英文名稱(chēng)	Anti-CIP2A Polyclonal Antibody
宿主	Rabbit
別名	CIP2A;KIAA1524;Protein CIP2A;p90
應(yīng)用	WB
稀釋比例	WB 1:500-2000.
交叉反應(yīng)	Human
蛋白分子量	102kd
Gene ID	57650
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	Recombinant protein of human CIP2A
性狀	液體
Public Immunogen Range	Recombinant protein of human CIP2A
Subcellular Locations	Cytoplasm Cell membrane
Swiss Prot	Q8TCG1
克隆類(lèi)型	Polyclonal Antibody
背景資料	Cancerous inhibitor of protein phosphatase 2A (CIP2A), also designated p90 autoantigen or KIAA1524, is a single-pass membrane protein that exhibits oncogenic activity. CIP2A is known to inhibit PP2A (protein phosphatase 2A) dephosphorylation of c-Myc, thereby stabilizing c-Myc (an oncogenic transcription factor) and promoting tumor formation and malignant cell growth. PP2A is a trimeric protein complex consisting of three subunits: a scaffold subunit, a catalytic subunit and a regulatory subunit. CIP2A specifically interacts with the catalytic subunit of PP2A to inhibit its activity. Inhibition of PP2A activity is a crucial step allowing for the progression of human cell transformation. Further supporting its role as an oncoprotein, CIP2A is known to be overexpressed in colon, gastric, and head and neck squamous cell carcinomas.