Anti-ERK1 Polyclonal Antibody
應(yīng)用 WB IHC
稀釋比例WB 1:2000-5000.IHC 1:50-200.
交叉反應(yīng) Human Mouse Rat

產(chǎn)品型號(hào)：K106454P

更新時(shí)間：2022-08-15

廠商性質(zhì)：生產(chǎn)廠家

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標(biāo)簽抗體血清球蛋白 IgG Polyclonal Antibody Antibody Monoclonal Antibody 一抗內(nèi)參抗體膠體金標(biāo)記二抗生物素化二抗 RBITC熒光標(biāo)記抗體二抗 FITC熒光標(biāo)記抗體二抗免疫血清二抗純化抗體二抗 HRP標(biāo)記二抗免疫球蛋白抗原IgG二抗

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Anti-ERK1 Polyclonal Antibody

英文名稱(chēng)	Anti-ERK1 Polyclonal Antibody
宿主	Rabbit
別名	MAPK 3;p44-MAPK;p44-ERK1;PRKM3;MAPK3
應(yīng)用	WB IHC
稀釋比例	WB 1:2000-5000.IHC 1:50-200.
蛋白分子量	43kDa
Gene ID	5594/5595
保存	Store at -20°C. Avoid freeze / thaw cycles.
儲(chǔ)存液	Buffer: PBS with 0.03% Proclin300, 50% glycerol, pH7.3.
純化方法	Affinity purification
亞型	IgG
免疫原	A synthetic peptide of human ERK1
性狀	液體
Public Immunogen Range	A synthetic peptide of human ERK1
Subcellular Locations	Cytoplasm Nucleus
Swiss Prot	P27361
克隆類(lèi)型	Polyclonal Antibody
背景資料	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, cytoskeletal rearrangements. The MAPK/ERK cascade plays also a role in initiation and regulation of meiosis, mitosis, and postmitotic functions in differentiated cells by phosphorylating a number of transcription factors. About 160 substrates have already been discovered for ERKs. Many of these substrates are localized in the nucleus, and seem to participate in the regulation of transcription upon stimulation. However, other substrates are found in the cytosol as well as in other cellular organelles, and those are responsible for processes such as translation, mitosis and apoptosis. Moreover, the MAPK/ERK cascade is also involved in the regulation of the endosomal dynamics, including lysosome processing and endosome cycling through the perinuclear recycling compartment (PNRC); as well as in the fragmentation of the Golgi apparatus during mitosis. The substrates include transcription factors (such as ATF2, BCL6, ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG), regulators of translation (such as EIF4EBP1) and a variety of other signaling-related molecules (like ARHGEF2, FRS2 or GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2, RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2, RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which enable the propagation the MAPK/ERK signal to additional cytosolic and nuclear targets, thereby extending the specificity of the cascade.